abstract：:IL-20 is an arteriogenic cytokine that remodels collateral networks in vivo, and plays a role in cellular organization. Here, we investigate its role in lymphangiogenesis using a lymphatic endothelial cell line, hTERT-HDLEC, which expresses the lymphatic markers LYVE-1 and podoplanin. Upon stimulation of hTERT-HDLEC w...

journal_title：Microvascular research

authors： Hammer T,Tritsaris K,Hübschmann MV,Gibson J,Nisato RE,Pepper MS,Dissing S

更新日期：2009-06-01 00:00:00

abstract：:We investigated the kinetics of human mesenchymal stem cells (MSCs) after intravascular administration into SCID mouse cremaster vasculature by intravital microscopy. MSCs were injected into abdominal aorta through left femoral artery at two different concentrations (1 x 10(6) or 0.2 x 10(6) cell). Arterial blood velo...

journal_title：Microvascular research

authors： Furlani D,Ugurlucan M,Ong L,Bieback K,Pittermann E,Westien I,Wang W,Yerebakan C,Li W,Gaebel R,Li RK,Vollmar B,Steinhoff G,Ma N

更新日期：2009-05-01 00:00:00

abstract：:Alveolar epithelial and endothelial cell death caused by mechanical over-distension is likely to contribute to ventilator-induced lung injury (VILI). Consequently, the search for cytoprotective interventions is of interest. We investigated the effect of the mTOR inhibitor rapamycin on human pulmonary microvascular end...

journal_title：Microvascular research

authors： Raaz U,Kuhn H,Wirtz H,Hammerschmidt S

更新日期：2009-05-01 00:00:00

abstract：:Microalbuminuria is a primary manifestation of diabetic nephropathy. Endothelial cell-selective adhesion molecule (ESAM) is a new member of the immunoglobulin superfamily which is selectively expressed by vascular endothelial cells. Although ESAM mediates homophilic interaction between endothelial cells, the role of E...

journal_title：Microvascular research

authors： Hara T,Ishida T,Cangara HM,Hirata K

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Vascular endothelial cells (ECs) are constantly exposed to blood flow associated forces such as cyclic strain due to blood pressure, which affects ECs survival and angiogenesis by producing ROS via NAD(P)H oxidase. NAD(P)H oxidase subunit p22phox is reported to be related to the development of atherosclerosis...

journal_title：Microvascular research

authors： Kou B,Zhang J,Singer DR

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Microvascular perfusion is indispensable for the growth and remodulation of membrane bone. Trauma, inflammation and surgical interventions may alter periosteal perfusion. However, there is not much known about periosteal perfusion in membrane bones. Therefore, the aim of this study was to establish a new chro...

journal_title：Microvascular research

authors： Stuehmer C,Schumann P,Bormann KH,Laschke MW,Menger MD,Gellrich NC,Rücker M

更新日期：2009-03-01 00:00:00

abstract：:Excessive generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), by activated neutrophils and endothelial cells, has been implicated in the pathophysiology of endothelial barrier dysfunction. Disruption of the integrity of this barrier markedly increases permeability to fluids, solutes and in...

journal_title：Microvascular research

authors： Boueiz A,Hassoun PM

更新日期：2009-01-01 00:00:00

abstract：:An increasing body of evidence suggests that the deleterious effects of Acute Kidney Injury (AKI) on remote organ function could, at least in part, be due to loss of the normal balance of immune, inflammatory, and soluble mediator metabolism that attends injury of the tubular epithelium. Such dysregulation, acting at ...

journal_title：Microvascular research

authors： Paladino JD,Hotchkiss JR,Rabb H

更新日期：2009-01-01 00:00:00

abstract：:The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cel...

journal_title：Microvascular research

authors： Bogatcheva NV,Verin AD

更新日期：2008-11-01 00:00:00

abstract：:Laser Doppler flowmetry (LDF) of forearm skin blood flow, combined with iontophoretically-administered acetylcholine and sodium nitroprusside and wavelet spectral analysis, was used for noninvasive evaluation of endothelial function in 17 patients newly diagnosed with New York Heart Association class II-III congestive...

journal_title：Microvascular research

authors： Bernjak A,Clarkson PB,McClintock PV,Stefanovska A

更新日期：2008-11-01 00:00:00

abstract：:In diabetic patients small fiber neuropathy has been associated with impairment of 0.1 Hz microvascular vasomotion. The aim of this study was (1) to investigate whether vasoconstriction-induced microvascular oscillations in the skin are reduced in diabetic patients with peripheral and/or autonomic neuropathy, and (2) ...

journal_title：Microvascular research

authors： Schmiedel O,Nurmikko TJ,Schroeter ML,Whitaker R,Harvey JN

更新日期：2008-08-01 00:00:00

abstract：:Liposomally formulated siRNA can be used for RNAi applications in vivo. Intravenous bolus administration of lipoplexed siRNA has been shown to reduce gene expression in the vascular endothelium. Here, we applied immunofluorescence staining for different endothelial markers (PECAM-1, CD34, laminin) on paraffin sections...

journal_title：Microvascular research

authors： Aleku M,Fisch G,Möpert K,Keil O,Arnold W,Kaufmann J,Santel A

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To assess the morphology of the lymphatic system pre- and postoperatively in patients undergoing microsurgical reconstructions of the lymphatic vessels. MATERIALS AND METHODS:8 lower extremities in 4 consecutive patients with secondary unilateral lymphedema of the lower extremities were examined by MR lympha...

journal_title：Microvascular research

authors： Lohrmann C,Felmerer G,Foeldi E,Bartholomä JP,Langer M

更新日期：2008-05-01 00:00:00

abstract：:Endoneurial capillaries in nerve biopsies from 12 adult diabetic cats with varying degrees of neurological dysfunction were examined for evidence of microvascular pathology and compared to nerves obtained at necropsy from 7 adult non-diabetic cats without clinical evidence of neurological dysfunction. As reported prev...

journal_title：Microvascular research

authors： Estrella JS,Nelson RN,Sturges BK,Vernau KM,Williams DC,LeCouteur RA,Shelton GD,Mizisin AP

更新日期：2008-04-01 00:00:00

abstract：:7-Ketocholesterol (7kCh) is a major oxysterol found associated with vascular diseases. Human microvascular endothelial cells (HMVECs) were cultured with different concentrations of 7kCh with and without inhibitors. Cell viabilities and caspase activities were assessed. 7kCh caused loss of cell viability in a dose-depe...

journal_title：Microvascular research

authors： Luthra S,Dong J,Gramajo AL,Chwa M,Kim DW,Neekhra A,Kuppermann BD,Kenney MC

更新日期：2008-04-01 00:00:00

abstract：:A novel first-pass imaging method for studying blood flow in tumors and normal tissues in mouse dorsal window chamber preparations is reported in this study. A fluorescence-labeled macromolecule is administered i.v. as a bolus dose, and the signal generated by the bolus is detected as the bolus passes through the vasc...

journal_title：Microvascular research

authors： Øye KS,Gulati G,Graff BA,Gaustad JV,Brurberg KG,Rofstad EK

更新日期：2008-03-01 00:00:00

abstract：:Estrogen induces endothelial progenitor cells (EPCs) migration and proliferation, which may serve as a potential target for coronary artery disease, but the mechanisms are unclear. We hypothesized that estrogen receptors (ERs) and phosphatidylinositol 3-kinase (PI3K) signaling pathway, which represent particularly imp...

journal_title：Microvascular research

authors： Zhao X,Huang L,Yin Y,Fang Y,Zhao J,Chen J

更新日期：2008-01-01 00:00:00

abstract：:Current tissue engineering techniques have failed to provide an established microvasculature in skin substitutes, a requisite for the maintenance of graft viability and rapid revascularization subsequent to graft transplantation in vivo. To improve outcomes for both conventional skin grafts and skin substitutes, the e...

journal_title：Microvascular research

authors： Wu X,Kathuria N,Patrick CW,Reece GP

更新日期：2008-01-01 00:00:00

abstract：:The concept of anti-angiogenesis therapy was introduced by Judah Folkman in 1971 and since then, a plethora of pro- and anti-angiogenic factors have been identified. In the recent years, it has become clear that angiogenesis, the formation of new capillaries from a pre-existing capillary network, is highly regulated b...

journal_title：Microvascular research

authors： Mundel TM,Kalluri R

更新日期：2007-09-01 00:00:00

abstract：:Endometriosis, the presence of endometrium-like tissue outside of the uterine cavity, is a common disease among women of reproductive age. Typical symptoms include abdominal pain and painful menstruation. In addition, endometriosis is associated with reduced fertility. Current treatment modalities, the surgical remova...

journal_title：Microvascular research

authors： Becker CM,D'Amato RJ

更新日期：2007-09-01 00:00:00

abstract：:The role of VEGF during development and in pathology is well known, but its function in normal adult tissues is poorly understood. Adverse effects associated with the use of anti-angiogenic therapies targeting VEGF in human pathologies have begun to reveal potential functions of VEGF in quiescent vasculature. Further ...

journal_title：Microvascular research

authors： Maharaj AS,D'Amore PA

更新日期：2007-09-01 00:00:00

abstract：:We examined the impact of lymph flow obstruction in large post-nodal lymphatic vessels in sheep. A silk ligature was placed 2 cm downstream from the prescapular or popliteal lymph node and tightened to interrupt flow. At 6, 12 and 16 weeks after lymph flow blockage, a network of small interconnecting lymphatics (appro...

journal_title：Microvascular research

authors： Jila A,Kim H,Nguyen VP,Dumont DJ,Semple J,Armstrong D,Seto E,Johnston M

更新日期：2007-05-01 00:00:00

abstract：:Ischemia/Reperfusion injury and hemolysis are characterized by erythrocyte lysis and release of free heme into the microcirculation. Following substantial erythrocyte lysis, heme overwhelms circulatory heme-binding protein networks rapidly forming hemin, the oxidized form of iron protoporphyrin IX. Hemin's role in mod...

journal_title：Microvascular research

authors： Natarajan R,Fisher BJ,Fowler AA 3rd

更新日期：2007-05-01 00:00:00

abstract：:The aim of our study was to evaluate the feasibility of laser Doppler flowmetry (LDF) coupled with iontophoresis in exploring the skin vasodilator activity of exogenous calcitonin gene-related peptide (CGRP) in healthy subjects and to investigate the mechanisms involved in the skin vasodilator activity of this peptide...

journal_title：Microvascular research

authors： Rossi M,Carpi A,Di Maria C,Galetta F,Santoro G

更新日期：2007-03-01 00:00:00

abstract：:Quantum dots (QDs) are fluorescent semiconductor nanocrystals that possess a number of superior fluorescent properties compared to more established organic dyes and fluorescent proteins. As a result, QDs are being studied for use in a wide range of biological applications. We have examined QDs for one such application...

journal_title：Microvascular research

authors： Smith JD,Fisher GW,Waggoner AS,Campbell PG

更新日期：2007-03-01 00:00:00

abstract：:Synthetic big endothelin-1 (ET-1), a 39-residue precursor of ET-1, has been reported to elicit potent contractile action on helical strip specimens obtained from the porcine coronary artery, but its molar potency was found to be 140-fold lower than that of ET-1 [Saito, Y., Nakao, K., Mukoyama, M., Imura, H., 1990. Inc...

journal_title：Microvascular research

authors： Abdelhalim MA

更新日期：2006-11-01 00:00:00

abstract：:A microfluidic device was developed for quantifying the migratory and deformability capabilities of a single tumor cell using direct imaging. It was fabricated using photolithography and is made of polydimethysiloxane. Chemotaxis approach was used for directing cell movement, using 10 microm microgaps to restrict the ...

journal_title：Microvascular research

authors： Chaw KC,Manimaran M,Tay FE,Swaminathan S

更新日期：2006-11-01 00:00:00

abstract：:Particle tracking velocimetry provides a Lagrangian description of flow properties in the microcirculation. To determine the utility of fluorescent nanoparticles to provide Lagrangian coordinates, we tracked these particles both in vitro and in vivo. The particles had a neutral charge and fluorescence intensity greate...

journal_title：Microvascular research

authors： Ravnic DJ,Zhang YZ,Tsuda A,Pratt JP,Huss HT,Mentzer SJ

更新日期：2006-07-01 00:00:00

abstract：:Cerebral ischemia and post-ischemic reperfusion commonly result in significant brain damage. Brain microvessel endothelial cells, the key target cells and regulating sites, can secrete adenosine which plays an important neuroprotective role in the ischemic brain. A primary determinant of localized production of adenos...

journal_title：Microvascular research

authors： Li X,Zhou T,Zhi X,Zhao F,Yin L,Zhou P

更新日期：2006-07-01 00:00:00

abstract：:Angiotensin II (Ang II), the dominant effector of the renin-angiotensin system, elicits numerous inflammatory-proliferative responses, thereby being involved in angiogenesis. T cells play an important role in angiogenesis as well by delivering vascular endothelial growth factor (VEGF) to inflammatory sites. Since we h...

journal_title：Microvascular research

authors： Yamagishi S,Matsui T,Nakamura K,Yoshida T,Shimizu K,Takegami Y,Shimizu T,Inoue H,Imaizumi T

更新日期：2006-05-01 00:00:00

abstract：:The study of angiogenesis as a therapeutic target requires reliable in vivo assays that can provide physiologically relevant data. A murine in vivo Matrigel-based angiogenesis assay is presented here which includes the quantitative assessment of vascular-specific indicators of neovascularization. Matrigel containing 1...

journal_title：Microvascular research

authors： Baker JH,Huxham LA,Kyle AH,Lam KK,Minchinton AI

更新日期：2006-03-01 00:00:00

abstract：:The contribution of the pleural mesothelium to pleural liquid and protein transport is still vigorously debated. Recent in vitro studies of stripped pleural membrane and free-standing pericardium have demonstrated active ion solute coupled transport of liquid and transcytosis of protein. However, the relative contribu...

journal_title：Microvascular research

authors： Tang SM,Lai-Fook SJ

更新日期：2005-11-01 00:00:00

abstract：:Controversy exists concerning whether activation of N-methyl-D-aspartate (NMDA) receptors exerts direct dilator effects on cerebral arteries. The purpose of this study was to examine the responses of isolated piglet arteries to NMDA to determine whether isolated arteries, apart from surrounding neuronal tissue, are ca...

journal_title：Microvascular research

authors： Simandle SA,Kerr BA,Lacza Z,Eckman DM,Busija DW,Bari F

更新日期：2005-07-01 00:00:00

abstract：:In the present study, human myometrial microvascular endothelial cells (HMMEC) were cocultured with human vascular smooth muscle cells (VSMC) labeled with fluorescent dyes to examine their morphological interaction using confocal laser fluorescent microscopy. HMMEC and VSMC labeled with fluorescent green and red dyes,...

journal_title：Microvascular research

authors： Burch MG,Pepe GJ,Dobrian AD,Lattanzio FA Jr,Albrecht ED

更新日期：2005-07-01 00:00:00

abstract：:The Raynaud's phenomenon often accompanies systemic rheumatic diseases and is also known as a vascular side effect of chemotherapy. Therapy of the Raynaud's phenomenon with nitrates or calcium-channel-blockers is rarely beneficial. In contrast, the PDE-V-inhibitor sildenafil seems to be effective in these patients. Fo...

journal_title：Microvascular research

authors： Baumhaekel M,Scheffler P,Boehm M

更新日期：2005-05-01 00:00:00

abstract：:Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis in the mammalian eye, suggesting that loss of PEDF is implicated in the pathogenesis of proliferative diabetic retinopathy. However, a role for PEDF in early diabetic retinopathy remains to be elucidated. Since oxidative stress is thought t...

journal_title：Microvascular research

authors： Amano S,Yamagishi S,Inagaki Y,Nakamura K,Takeuchi M,Inoue H,Imaizumi T

更新日期：2005-01-01 00:00:00

abstract：:The study deals with the adhesion and proliferation of bovine retina pericytes onto surfaces of poly(hydroxymethylsiloxane) (PHMS) modified either by cold plasma or by low-energy ion beams. The surface treatment was able to convert the original polymer matrix into SiO2-like phases for O2-plasma or ion-mixed SiCxOy(Hz)...

journal_title：Microvascular research

authors： Assero G,Satriano C,Lupo G,Anfuso CD,Marletta G,Alberghina M

更新日期：2004-11-01 00:00:00

abstract：:This study further investigates the mechanisms responsible for the effects of acute and severe hypoxia, and subsequent reoxygenation, on the contractility of isolated rat mesenteric arteries. In noradrenaline (NA)-contracted arteries, hypoxia caused a relaxation to near baseline levels. Reoxygenation resulted in an im...

journal_title：Microvascular research

authors： Bruce J,Taggart M,Austin C

更新日期：2004-11-01 00:00:00

abstract：:The most universal angiogenic cytokines (VEGF, bFGF, HGF) are all heparin-binding proteins, the function of which is dependent on cell surface heparan sulfate proteoglycans (HSPG). Several proteoglycans have been demonstrated in endothelial cells, but only glypican-1 from the cell surface HSPG subfamily was documented...

journal_title：Microvascular research

authors： Forster-Horváth C,Mészáros L,Rásó E,Döme B,Ladányi A,Morini M,Albini A,Tímár J

更新日期：2004-09-01 00:00:00

abstract：:To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the postcapillary venules of rat mesentery in vivo. Exposure to 1 nM VEGF transiently increased P from a mean of 1.4 (+/-0.11 SE...

journal_title：Microvascular research

authors： Fu BM,Shen S

更新日期：2004-07-01 00:00:00